Applikon AppliSens sensors

Bioprocess sensors with the same precision as you

In the biotech- and pharmaceutical industry it is vital to have precise information about the process values of the bioprocess. These values directly affect viability, productivity, stability of the cells and influence the analysis of active ingredients. The AppliSens sensors are specifically designed for long-term, stable and accurate measurements in bioprocesses.

Continuous measurement of parameters enable process optimization and product yield maximization

Stable signal over longer time
Easy calibration and short response time
Low sensitivity to fouling and thus drifting

Proper control of a bioprocess requires reliable monitoring of many process parameters. From basic physiochemical properties such as pH or dissolved oxygen to determination of biomass density or metabolite concentrations, Getinge offers several process analytical technologies (PAT) for making sophisticated measurements of your bioprocess.

FIND OUT MORE ABOUT ADDING SENSORS TO YOUR PROCESS HERE

A variety of sensors for every need.

Applikon offers a number of process analytical technologies (PAT) to get the very best measurements from your process. The AppliSens range of sensors are designed for easy calibration, short response time and long-term stability to help you get the most reliable results.

Features of the AppliSens range of biotechnology sensors.

As with many other Applikon products, the AppliSens sensors are designed with every user in mind. This means they feature a robust, compact design and allow for easy setup by taking up minimal space on the bioreactor top plate.

Applikon is a full solution provider. The aim is to make your process as easy-to-use and accurate as possible. Therefore, many of our biotechnology sensors have a driver that is built-in to the Applikon controller software. This way, you can get sensor data, information (e.g. health status) and sensor operating parameters (e.g. calibration) immediately. It’s possible to have direct integration with the following sensors:

AppliSens pH Sensor
AppliSens DO Sensor
AppliSens RedOx Sensor

Save investment costs and bench space without the need for an external transmitter. Plus, there’s no need for additional software, meaning easy operator training and cost saving of additional software.

The AppliSens sensors allow you to generate:

One sample every x minutes instead of one measurement from an offline measurement per day.
Online data, meaning fast response and full control of key process parameters.
Accurately duplicated data because samples are measured in exactly the same way every time = no more operator to operator variation.

GET IN TOUCH NOW TO ADD APPLIKON SENSORS TO YOUR BIOPROCESS.

Customer questions and recessions

The biotechnology sensor range from Applikon can be used in the following applications:

Fundamental
Research
Optimization
Pilot Plant
Manufacturing
Process development
Screening

Yes! If you need to achieve biomass measurements during your process, we can help with that. At Resea Biotec, we can provide various additional sensors so you can gain true process control and monitoring with less workload.

We offer Call Density Sensors for biomass measurement that provide both Viable Cell Density and Optical Density analysis.

Also available are the Hamilton ARC sensors that further eases your bioprocess by rethinking communication between sensors, end users and process control systems. ARC sensors omit the need for a traditional transmitter by communicating directly with the Applikon process control system.

All Applikon sensors can be connected via USB connection or direct integration:

LumiSens Optical DO Sensor
AppliSens DO Sensor
AppliSens pH Sensor

Some third party additional sensors (compatible with Applikon bioreactors) are also available via USB connection:

Hamilton DO and pH (ARC)
Hamilton Densytee and Incyte
Mettler Toledo pH, DO and CO2 (ISM)
BugLab BE2100 and BugLab BE3000
ABER Futura Biomass
SBI Balance
HiTec Zang Balance
Presens optical pH/DO

It’s also possible to connect some sensors via analog connection (Note: ADDA, Analog Input License or SIP board required):

BlueSens CO2, BlueSens O2
BlueInOne CO2/O2
BlueVary
Loadcells
FoamFighter
Optek OD Senso
…and more.

An important addition to your bioprocess.

Can you really get all the values and information you need right now from your standard sensors? The intelligent and optical sensors provided by Applikon are easily integrated into your system and can give you the results you need within minutes.

With the addition of further sensors like offgas, biomass and balances, you can also get even more vital information that will help your long-term cultivation.

Your bioprocess needs precision. Your bioprocess needs Applikon biotechnology sensors.

Do you want to know more? Contact us and our expert team will be happy to help!

Optical DO: LumiSens

Stable signal over longer time
Easy calibration and short response time
Low sensitivity to fouling and thus drifting

The Applikon LumiSens sensor can be used right after autoclaving. Polarization is no longer needed, compared to the traditional polarographic DO₂ sensors, and the need for calibration is significantly decreased to only once per year instead of calibrating for every run. The electrolyte and membranes don't need replacement, reducing maintenance costs. The RedFlash optical technology allows accurate measurements especially in the low oxygen concentration range where classic probes are less accurate. The smart sensor design separates the electronics from the glass sensor part, guaranteeing a long sensor life with repeated sterilizations.

Traditional DO2 Sensors

Easy calibration
Low drift by usage of titanium and PEEK material
Optimal cleanability due to fully electro-polished surface

Measurements of dissolved oxygen (DO₂) in biotechnological processes is a basis for process optimization and maximization of the product yield. A microorganism or cell responds to the oxygen concentration in regulating its overall metabolism. Therefore, knowledge of the DO₂ concentration and its proper control during the process are of great importance. The AppliSens DO₂-sensor is specifically designed for long-term, stable and accurate measurements in bioprocesses. The DO₂-sensor has a titanium membrane module to minimize the measurement drift.

pH Sensors

Accurate measurement
Stable signal over longer time
Low sensitivity to fouling and thus drifting due to sleeve diaphragm

Within upstream bioprocessing it is vital to have precise information about the pH value of the bioprocess. The pH level directly affects viability, productivity, and stability of the cells and it influences the analysis of active ingredients. The AppliSens pH+ sensor has a fixed sleeve diaphragm that reduces the influence of the culture medium on the pH measurement. Compared to classic diaphragm types, this sleeve diaphragm increases measuring accuracy and the lifetime of the sensor which is vital for long lasting biotech cultivation processes.

RedOx Sensors

Accurate measurement
Short response time
Stable signal over longer time

The RedOx potential (Reduction / Oxidation) of a bioreactor culture can be measured using a RedOx sensor. The value of the reading of the sensor can depend on pH, growth phase, growth medium components, and fermentation endproducts (especially fermentation acids and hydrogen). RedOx measurement is also used in anaerobic fermentations as an alternative to the Dissolved Oxygen sensor which does not give much process information in anaerobic situations.